Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2364367..2364884 | Replicon | chromosome |
| Accession | NZ_CP062402 | ||
| Organism | Staphylococcus aureus strain NAS_OP_056 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | IF766_RS11650 | Protein ID | WP_000113262.1 |
| Coordinates | 2364367..2364633 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | IF766_RS11655 | Protein ID | WP_000584499.1 |
| Coordinates | 2364633..2364884 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF766_RS11620 (IF766_11560) | 2359790..2360326 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| IF766_RS11625 (IF766_11565) | 2360560..2361384 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| IF766_RS11630 (IF766_11570) | 2361601..2361783 | - | 183 | WP_000079142.1 | hypothetical protein | - |
| IF766_RS11635 (IF766_11575) | 2361870..2362337 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| IF766_RS11640 (IF766_11580) | 2362523..2364073 | - | 1551 | WP_000727763.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IF766_RS11645 | 2364261..2364332 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| IF766_RS11650 (IF766_11585) | 2364367..2364633 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| IF766_RS11655 (IF766_11590) | 2364633..2364884 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IF766_RS11660 (IF766_11595) | 2365049..2365129 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| IF766_RS11665 (IF766_11600) | 2365157..2365756 | - | 600 | WP_000162803.1 | DsbA family protein | - |
| IF766_RS11670 (IF766_11605) | 2365775..2366137 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| IF766_RS11675 (IF766_11610) | 2366392..2367642 | + | 1251 | WP_001012228.1 | FemA/FemB family glycyltransferase FmhA | - |
| IF766_RS11680 (IF766_11615) | 2367739..2368470 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| IF766_RS11685 (IF766_11620) | 2368467..2369186 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T174912 WP_000113262.1 NZ_CP062402:c2364633-2364367 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T174912 NZ_CP081706:c2600726-2600550 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT174912 WP_000584499.1 NZ_CP062402:c2364884-2364633 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT174912 NZ_CP081706:c2600504-2600088 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|