Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2785710..2786124 | Replicon | chromosome |
| Accession | NZ_CP062401 | ||
| Organism | Staphylococcus aureus strain NAS_OP_098 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | IF770_RS13885 | Protein ID | WP_001065046.1 |
| Coordinates | 2785710..2785961 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | IF770_RS13890 | Protein ID | WP_000028424.1 |
| Coordinates | 2785951..2786124 (+) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF770_RS13845 (2781367) | 2781367..2782287 | + | 921 | WP_000138475.1 | recombinase RecT | - |
| IF770_RS13850 (2782368) | 2782368..2782985 | + | 618 | WP_072353921.1 | MBL fold metallo-hydrolase | - |
| IF770_RS13855 (2782986) | 2782986..2783456 | + | 471 | WP_000934762.1 | single-stranded DNA-binding protein | - |
| IF770_RS13860 (2783486) | 2783486..2784379 | + | 894 | WP_000148327.1 | DnaD domain-containing protein | - |
| IF770_RS13865 (2784386) | 2784386..2784604 | + | 219 | WP_000338527.1 | hypothetical protein | - |
| IF770_RS13870 (2784613) | 2784613..2785068 | + | 456 | WP_000401965.1 | RusA family crossover junction endodeoxyribonuclease | - |
| IF770_RS13875 (2785081) | 2785081..2785449 | + | 369 | WP_000101270.1 | SA1788 family PVL leukocidin-associated protein | - |
| IF770_RS13880 (2785453) | 2785453..2785695 | + | 243 | WP_000131381.1 | phi PVL orf 51-like protein | - |
| IF770_RS13885 (2785710) | 2785710..2785961 | + | 252 | WP_001065046.1 | DUF1024 family protein | Toxin |
| IF770_RS13890 (2785951) | 2785951..2786124 | + | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| IF770_RS13895 (2786150) | 2786150..2786407 | + | 258 | WP_031866878.1 | hypothetical protein | - |
| IF770_RS13900 (2786408) | 2786408..2786569 | + | 162 | WP_000889682.1 | hypothetical protein | - |
| IF770_RS13905 (2786584) | 2786584..2787117 | + | 534 | WP_001061838.1 | dUTPase | - |
| IF770_RS13910 (2787154) | 2787154..2787399 | + | 246 | WP_001282074.1 | hypothetical protein | - |
| IF770_RS13915 (2787396) | 2787396..2787602 | + | 207 | WP_000195803.1 | DUF1381 domain-containing protein | - |
| IF770_RS13920 (2787599) | 2787599..2787985 | + | 387 | WP_000592201.1 | hypothetical protein | - |
| IF770_RS13925 (2787982) | 2787982..2788131 | + | 150 | WP_000595305.1 | transcriptional activator RinB | - |
| IF770_RS13930 (2788290) | 2788290..2788940 | + | 651 | WP_001005262.1 | hypothetical protein | - |
| IF770_RS13935 (2788940) | 2788940..2789140 | + | 201 | WP_000265041.1 | DUF1514 family protein | - |
| IF770_RS13940 (2789163) | 2789163..2789633 | + | 471 | WP_000282758.1 | hypothetical protein | - |
| IF770_RS13945 (2789748) | 2789748..2790200 | + | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| IF770_RS13950 (2790216) | 2790216..2790560 | + | 345 | WP_000817289.1 | HNH endonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | hlb | 2769377..2791155 | 21778 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9377.26 Da Isoelectric Point: 3.7128
>T174904 WP_001065046.1 NZ_CP062401:2785710-2785961 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T174904 NZ_CP081706:836554-836838 [Escherichia coli]
GTGTATAAACTCACTGAACGGGCAGCAGACGACTTCGCCGGGATTTATGACTATACGCTCTTGAAATTTGGTGAAGCTCA
GGCAGACCATTATACAGACGCACTTGAGGCATTTTTCGAGACACTGGCCGGAATGCCAGATATGGGACGTGACTACCATA
CCGTTCCTGGTGTGATGCGCATTGAATTTCAGCGACATGCCATTTTTTATACGGTTCGTGATACGGATATTCTGATTGCG
CGTATTTTGCACCAACAGATGAACCATAAACGCCATTTACTGTAA
GTGTATAAACTCACTGAACGGGCAGCAGACGACTTCGCCGGGATTTATGACTATACGCTCTTGAAATTTGGTGAAGCTCA
GGCAGACCATTATACAGACGCACTTGAGGCATTTTTCGAGACACTGGCCGGAATGCCAGATATGGGACGTGACTACCATA
CCGTTCCTGGTGTGATGCGCATTGAATTTCAGCGACATGCCATTTTTTATACGGTTCGTGATACGGATATTCTGATTGCG
CGTATTTTGCACCAACAGATGAACCATAAACGCCATTTACTGTAA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT174904 WP_000028424.1 NZ_CP062401:2785951-2786124 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT174904 NZ_CP081706:836319-836561 [Escherichia coli]
ATGGCCAGAACAACAAGCGTTACGATTGGCGAACAACTCGATTCGTTTATTAGTCGATTAATAGACAGTGGCCGTTACGG
CTCTGCGAGTGAAGTTATGCGTTCTGCGCTGCGATTGCTGGAGCAACAGGAAACAAACGATGAAGTTATTCGTCAGGCTG
TTATTGCTGGGCTGGAAAGCGGTGAAAGCTCGCTATCACTGCGGGATATTGCAGCACAAAGAAAACTGAGACATCGTGTA
TAA
ATGGCCAGAACAACAAGCGTTACGATTGGCGAACAACTCGATTCGTTTATTAGTCGATTAATAGACAGTGGCCGTTACGG
CTCTGCGAGTGAAGTTATGCGTTCTGCGCTGCGATTGCTGGAGCAACAGGAAACAAACGATGAAGTTATTCGTCAGGCTG
TTATTGCTGGGCTGGAAAGCGGTGAAAGCTCGCTATCACTGCGGGATATTGCAGCACAAAGAAAACTGAGACATCGTGTA
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|