Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2378484..2379001 Replicon chromosome
Accession NZ_CP062401
Organism Staphylococcus aureus strain NAS_OP_098

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag IF770_RS11725 Protein ID WP_000113265.1
Coordinates 2378735..2379001 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF770_RS11720 Protein ID WP_000584499.1
Coordinates 2378484..2378735 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF770_RS11690 (2374182) 2374182..2374901 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF770_RS11695 (2374898) 2374898..2375629 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF770_RS11700 (2375726) 2375726..2376976 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
IF770_RS11705 (2377231) 2377231..2377593 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF770_RS11710 (2377612) 2377612..2378211 + 600 WP_000162810.1 DsbA family protein -
IF770_RS11715 (2378239) 2378239..2378319 + 81 WP_223197974.1 hypothetical protein -
IF770_RS11720 (2378484) 2378484..2378735 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF770_RS11725 (2378735) 2378735..2379001 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
IF770_RS11730 (2379036) 2379036..2379107 + 72 Protein_2280 hypothetical protein -
IF770_RS11735 (2379296) 2379296..2380843 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF770_RS11740 (2381029) 2381029..2381496 + 468 WP_000153347.1 SRPBCC domain-containing protein -
IF770_RS11745 (2381580) 2381580..2381762 + 183 WP_000230292.1 hypothetical protein -
IF770_RS11750 (2381979) 2381979..2382803 + 825 WP_000572038.1 formate/nitrite transporter family protein -
IF770_RS11755 (2383037) 2383037..2383573 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T174897 WP_000113265.1 NZ_CP062401:2378735-2379001 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174897 NZ_CP081706:c68166-67873 [Escherichia coli]
ATGGCTGTCGAGTTTAGAGACACGTGGCTGGAAGCGTTTTACGAGGATGACCAAAACCACAGGAGGATACCTAGTACCAT
CGAAGGCGCATTGTTCAGGAAGCTGGAGATCTTGGACGCAGCGACCCAGGAGTCAGACTTGAGAATCCCTCCGGGTAACC
GCTTCGAGCACCTTGAAGGGAATATGGCCGGGTGGTGTTCCATCCGGGTAAACAAGCAATACCGGCTGATCTTTAGATGG
ATCGATGGCGTTGCCCAAGATACTTATCTGGATCCTCATGTTTACAGGGGCTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT174897 WP_000584499.1 NZ_CP062401:2378484-2378735 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174897 NZ_CP081706:c67858-67532 [Escherichia coli]
ATGAGAAACACAAAACGTCGCCCAGTTACGGTCGGTCAGATGCTGGTAACCGAGTTCCTGGAGCCTATGAACATCGAGAT
CAACGAACTGGCTGAAGCCATGGGTGTGCACAGAAACACCCTGAGTCGGATCGTTCACGACAAGGGGGCATTGACCGCAC
CCATGTCAATCAAACTGGCAGCGGCCTTGGGTAACACGCCGGAGTTCTGGCTCAATATTCAGCACTCAGTAGAGTTGTGG
GATGTTCGGCATAGAGCCTTTGAGCAGGAAGCAAAGAATGTTAAACGAGTAACGCCTCACTTGGAGAACAGGGAAGCAGT
TATTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References