Detailed information of TA system TA174895

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2353322..2353506
• Replicon: chromosome
• Accession: NZ_CP062401
• Organism: Staphylococcus aureus strain NAS_OP_098

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: IF770_RS11590
• Protein ID: WP_000482652.1
• Coordinates: 2353322..2353429 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2353446..2353506 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF770_RS11565	2348684..2349157	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
IF770_RS11570	2349280..2350491	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF770_RS11575	2350673..2351332	-	660	WP_000831298.1	membrane protein	-
IF770_RS11580	2351392..2352534	-	1143	WP_001176863.1	glycerate kinase	-
IF770_RS11585	2352802..2353188	+	387	WP_000779360.1	flippase GtxA	-
IF770_RS11590	2353322..2353429	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2353446..2353506	-	61	-	-	Antitoxin
IF770_RS11595	2354132..2355895	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
IF770_RS11600	2355920..2357653	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
IF770_RS11605	2357920..2358051	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174895 WP_000482652.1 NZ_CP062401:2353322-2353429 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174895 NZ_CP081701:4072759-4072911 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174895 NZ_CP062401:c2353506-2353446 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin