Detailed information of TA system TA174891

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 216271..216451
• Replicon: chromosome
• Accession: NZ_CP062401
• Organism: Staphylococcus aureus strain NAS_OP_098

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF770_RS01420
• Protein ID: WP_001801861.1
• Coordinates: 216356..216451 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	216271..216328 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF770_RS01390	211980..212114	+	135	WP_001791797.1	hypothetical protein	-
IF770_RS01395	212278..213834	+	1557	WP_000028669.1	type I restriction-modification system subunit M	-
IF770_RS01400	213827..215056	+	1230	WP_000072627.1	restriction endonuclease subunit S	-
IF770_RS01405	215598..216008	+	411	WP_223200549.1	transposase	-
IF770_RS01410	215993..216154	+	162	Protein_243	transposase	-
IF770_RS01415	216132..216233	-	102	WP_001792025.1	hypothetical protein	-
-	216271..216328	+	58	-	-	Antitoxin
IF770_RS01420	216356..216451	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF770_RS01425	216596..217608	+	1013	Protein_246	IS3 family transposase	-
IF770_RS01430	217806..218378	-	573	WP_000414216.1	hypothetical protein	-
IF770_RS01435	218479..218820	-	342	WP_000627540.1	DUF3969 family protein	-
IF770_RS01440	218861..219487	-	627	WP_000669024.1	hypothetical protein	-
IF770_RS01445	219562..220557	-	996	WP_000070642.1	DUF4352 domain-containing protein	-
IF770_RS01450	220638..221288	-	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	141725..240470	98745

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174891 WP_001801861.1 NZ_CP062401:c216451-216356 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174891 NZ_CP081701:2803454-2803561 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT174891 NZ_CP062401:216271-216328 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin