Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2320404..2320921 | Replicon | chromosome |
| Accession | NZ_CP062400 | ||
| Organism | Staphylococcus aureus strain NAS_OP_107 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | IF772_RS11400 | Protein ID | WP_000113262.1 |
| Coordinates | 2320655..2320921 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | IF772_RS11395 | Protein ID | WP_000584499.1 |
| Coordinates | 2320404..2320655 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF772_RS11370 (2316248) | 2316248..2317567 | + | 1320 | WP_001808146.1 | ISL3-like element IS1181 family transposase | - |
| IF772_RS11375 (2317646) | 2317646..2318896 | - | 1251 | WP_001012223.1 | FemA/FemB family glycyltransferase FmhA | - |
| IF772_RS11380 (2319151) | 2319151..2319513 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| IF772_RS11385 (2319532) | 2319532..2320131 | + | 600 | WP_000162813.1 | DsbA family protein | - |
| IF772_RS11390 (2320138) | 2320138..2320239 | + | 102 | WP_031774922.1 | hypothetical protein | - |
| IF772_RS11395 (2320404) | 2320404..2320655 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IF772_RS11400 (2320655) | 2320655..2320921 | + | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| IF772_RS11405 (2320956) | 2320956..2321033 | + | 78 | Protein_2216 | hypothetical protein | - |
| IF772_RS11410 (2321217) | 2321217..2322767 | + | 1551 | WP_000727763.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IF772_RS11415 (2322953) | 2322953..2323420 | + | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| IF772_RS11420 (2323507) | 2323507..2323689 | + | 183 | WP_000079142.1 | hypothetical protein | - |
| IF772_RS11425 (2323906) | 2323906..2324730 | + | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| IF772_RS11430 (2324964) | 2324964..2325500 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2316248..2317567 | 1319 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T174880 WP_000113262.1 NZ_CP062400:2320655-2320921 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T174880 NZ_CP062400:2320655-2320921 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT174880 WP_000584499.1 NZ_CP062400:2320404-2320655 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT174880 NZ_CP062400:2320404-2320655 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|