Detailed information of TA system TA174878

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2293783..2293967
• Replicon: chromosome
• Accession: NZ_CP062400
• Organism: Staphylococcus aureus strain NAS_OP_107

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF772_RS11260
• Protein ID: WP_000482647.1
• Coordinates: 2293783..2293890 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2293907..2293967 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF772_RS11235	2289155..2289628	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF772_RS11240	2289751..2290962	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF772_RS11245	2291144..2291803	-	660	WP_000831298.1	membrane protein	-
IF772_RS11250	2291863..2293005	-	1143	WP_001176863.1	glycerate kinase	-
IF772_RS11255	2293263..2293649	+	387	WP_000779360.1	flippase GtxA	-
IF772_RS11260	2293783..2293890	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2293907..2293967	-	61	-	-	Antitoxin
IF772_RS11265	2294594..2296357	+	1764	WP_001064814.1	ABC transporter ATP-binding protein	-
IF772_RS11270	2296382..2298115	+	1734	WP_000486489.1	ABC transporter ATP-binding protein	-
IF772_RS11275	2298346..2298513	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174878 WP_000482647.1 NZ_CP062400:2293783-2293890 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174878 NZ_CP081701:187510-187617 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174878 NZ_CP062400:c2293967-2293907 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin