Detailed information of TA system TA174872

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2507433..2507956
• Replicon: chromosome
• Accession: NZ_CP062399
• Organism: Staphylococcus aureus strain NAS_OP_143

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: IF777_RS12490
• Protein ID: WP_000074043.1
• Coordinates: 2507433..2507699 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: IF777_RS12495
• Protein ID: WP_000587618.1
• Coordinates: 2507699..2507956 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF777_RS12470 (IF777_12420)	2502740..2503927	-	1188	WP_000026187.1	MFS transporter	-
IF777_RS12475 (IF777_12425)	2504321..2505097	-	777	WP_006191020.1	iron export ABC transporter permease subunit FetB	-
IF777_RS12480 (IF777_12430)	2505090..2505752	-	663	WP_006191024.1	ATP-binding cassette domain-containing protein	-
IF777_RS12485 (IF777_12435)	2506000..2507076	-	1077	WP_045172647.1	M42 family metallopeptidase	-
IF777_RS12490 (IF777_12440)	2507433..2507699	-	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
IF777_RS12495 (IF777_12445)	2507699..2507956	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF777_RS12500 (IF777_12450)	2508315..2508770	+	456	WP_000732091.1	DUF1307 domain-containing protein	-
IF777_RS12505 (IF777_12455)	2508938..2510515	-	1578	WP_000143494.1	FMN-binding glutamate synthase family protein	-
IF777_RS12510 (IF777_12460)	2510710..2511459	+	750	WP_000072463.1	CPBP family lipoprotein N-acylation protein LnsB	-
IF777_RS12515 (IF777_12465)	2511683..2512876	-	1194	WP_000675406.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T174872 WP_000074043.1 NZ_CP062399:c2507699-2507433 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T174872 NZ_CP081699:c88294-87914 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTCCAGGCCAGAGTTGTGTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACTGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT174872 WP_000587618.1 NZ_CP062399:c2507956-2507699 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT174872 NZ_CP081699:c88515-88294 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2