Detailed information of TA system TA174870

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2474897..2475081
• Replicon: chromosome
• Accession: NZ_CP062399
• Organism: Staphylococcus aureus strain NAS_OP_143

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF777_RS12345
• Protein ID: WP_000482647.1
• Coordinates: 2474974..2475081 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2474897..2474957 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF777_RS12330 (IF777_12280)	2470407..2470574	-	168	WP_001790576.1	hypothetical protein	-
IF777_RS12335 (IF777_12285)	2470805..2472538	-	1734	WP_070869570.1	ABC transporter ATP-binding protein	-
IF777_RS12340 (IF777_12290)	2472563..2474326	-	1764	WP_045172654.1	ABC transporter ATP-binding protein	-
-	2474897..2474957	+	61	-	-	Antitoxin
IF777_RS12345 (IF777_12295)	2474974..2475081	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
IF777_RS12350 (IF777_12300)	2475215..2475601	-	387	WP_000779360.1	flippase GtxA	-
IF777_RS12355 (IF777_12305)	2475869..2477011	+	1143	WP_001176863.1	glycerate kinase	-
IF777_RS12360 (IF777_12310)	2477071..2477730	+	660	WP_000831298.1	membrane protein	-
IF777_RS12365 (IF777_12315)	2477912..2479123	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF777_RS12370 (IF777_12320)	2479246..2479719	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174870 WP_000482647.1 NZ_CP062399:c2475081-2474974 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174870 NZ_CP081698:c4185057-4184707 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174870 NZ_CP062399:2474897-2474957 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin