Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2449522..2450039 | Replicon | chromosome |
| Accession | NZ_CP062399 | ||
| Organism | Staphylococcus aureus strain NAS_OP_143 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | IF777_RS12210 | Protein ID | WP_000113262.1 |
| Coordinates | 2449522..2449788 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | IF777_RS12215 | Protein ID | WP_000584499.1 |
| Coordinates | 2449788..2450039 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF777_RS12180 (IF777_12130) | 2444947..2445483 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| IF777_RS12185 (IF777_12135) | 2445717..2446541 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| IF777_RS12190 (IF777_12140) | 2446758..2446940 | - | 183 | WP_000079142.1 | hypothetical protein | - |
| IF777_RS12195 (IF777_12145) | 2447027..2447494 | - | 468 | WP_000153346.1 | SRPBCC domain-containing protein | - |
| IF777_RS12200 (IF777_12150) | 2447680..2449227 | - | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IF777_RS12205 (IF777_12155) | 2449416..2449487 | - | 72 | Protein_2361 | hypothetical protein | - |
| IF777_RS12210 (IF777_12160) | 2449522..2449788 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| IF777_RS12215 (IF777_12165) | 2449788..2450039 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IF777_RS12220 (IF777_12170) | 2450204..2450305 | - | 102 | WP_001791744.1 | hypothetical protein | - |
| IF777_RS12225 (IF777_12175) | 2450312..2450911 | - | 600 | WP_000162813.1 | DsbA family protein | - |
| IF777_RS12230 (IF777_12180) | 2450930..2451292 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| IF777_RS12235 (IF777_12185) | 2451547..2452797 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| IF777_RS12240 (IF777_12190) | 2452894..2453625 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| IF777_RS12245 (IF777_12195) | 2453622..2454341 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T174869 WP_000113262.1 NZ_CP062399:c2449788-2449522 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T174869 NZ_CP081698:4075656-4075997 [Escherichia coli]
ATGACTGACACGTATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGCCGCTACCCGGATCACGCGCATATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGCATCGTCCTCACCGCTCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCAGGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAATTTATTGGGGTGATTGC
CGGTAAACAGAAAGTTGCCTGA
ATGACTGACACGTATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGCCGCTACCCGGATCACGCGCATATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGCATCGTCCTCACCGCTCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCAGGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAATTTATTGGGGTGATTGC
CGGTAAACAGAAAGTTGCCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT174869 WP_000584499.1 NZ_CP062399:c2450039-2449788 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT174869 NZ_CP081698:c4075661-4075585 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|