Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2394409..2394593 Replicon chromosome
Accession NZ_CP062398
Organism Staphylococcus aureus strain NAS_OP_154

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag IF781_RS11895 Protein ID WP_000482652.1
Coordinates 2394486..2394593 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2394409..2394469 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF781_RS11880 (IF781_11820) 2389864..2389995 - 132 WP_223197975.1 hypothetical protein -
IF781_RS11885 (IF781_11825) 2390262..2391995 - 1734 WP_000486487.1 ABC transporter ATP-binding protein -
IF781_RS11890 (IF781_11830) 2392020..2393783 - 1764 WP_001064825.1 ABC transporter ATP-binding protein -
- 2394409..2394469 + 61 - - Antitoxin
IF781_RS11895 (IF781_11835) 2394486..2394593 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
IF781_RS11900 (IF781_11840) 2394727..2395113 - 387 WP_000779360.1 flippase GtxA -
IF781_RS11905 (IF781_11845) 2395381..2396523 + 1143 WP_001176863.1 glycerate kinase -
IF781_RS11910 (IF781_11850) 2396583..2397242 + 660 WP_000831298.1 membrane protein -
IF781_RS11915 (IF781_11855) 2397424..2398635 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
IF781_RS11920 (IF781_11860) 2398758..2399231 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T174861 WP_000482652.1 NZ_CP062398:c2394593-2394486 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T174861 NZ_CP081698:2049350-2049453 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 61 bp

>AT174861 NZ_CP062398:2394409-2394469 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References