Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2369051..2369568 Replicon chromosome
Accession NZ_CP062398
Organism Staphylococcus aureus strain NAS_OP_154

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag IF781_RS11760 Protein ID WP_000113265.1
Coordinates 2369051..2369317 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF781_RS11765 Protein ID WP_000584499.1
Coordinates 2369317..2369568 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF781_RS11730 (IF781_11670) 2364479..2365015 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
IF781_RS11735 (IF781_11675) 2365249..2366073 - 825 WP_000572038.1 formate/nitrite transporter family protein -
IF781_RS11740 (IF781_11680) 2366290..2366472 - 183 WP_000230292.1 hypothetical protein -
IF781_RS11745 (IF781_11685) 2366556..2367023 - 468 WP_000153347.1 SRPBCC domain-containing protein -
IF781_RS11750 (IF781_11690) 2367209..2368756 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF781_RS11755 (IF781_11695) 2368945..2369016 - 72 Protein_2271 hypothetical protein -
IF781_RS11760 (IF781_11700) 2369051..2369317 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
IF781_RS11765 (IF781_11705) 2369317..2369568 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF781_RS11770 (IF781_11710) 2369733..2369813 - 81 WP_223197974.1 hypothetical protein -
IF781_RS11775 (IF781_11715) 2369841..2370440 - 600 WP_000162810.1 DsbA family protein -
IF781_RS11780 (IF781_11720) 2370459..2370821 - 363 WP_000819843.1 DUF4467 domain-containing protein -
IF781_RS11785 (IF781_11725) 2371076..2372326 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
IF781_RS11790 (IF781_11730) 2372423..2373154 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF781_RS11795 (IF781_11735) 2373151..2373870 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T174860 WP_000113265.1 NZ_CP062398:c2369317-2369051 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174860 NZ_CP081698:1098880-1099191 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT174860 WP_000584499.1 NZ_CP062398:c2369568-2369317 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174860 NZ_CP081698:1099188-1099607 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References