Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | sprA1-sprA1AS/- |
| Location | 1826321..1826501 | Replicon | chromosome |
| Accession | NZ_CP062398 | ||
| Organism | Staphylococcus aureus strain NAS_OP_154 | ||
Toxin (Protein)
| Gene name | sprA1 | Uniprot ID | - |
| Locus tag | IF781_RS08805 | Protein ID | WP_001801861.1 |
| Coordinates | 1826321..1826416 (+) | Length | 32 a.a. |
Antitoxin (RNA)
| Gene name | sprA1AS | ||
| Locus tag | - | ||
| Coordinates | 1826444..1826501 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF781_RS08775 (IF781_08730) | 1821484..1822134 | + | 651 | WP_001795210.1 | excalibur calcium-binding domain-containing protein | - |
| IF781_RS08780 (IF781_08735) | 1822215..1823210 | + | 996 | WP_000070642.1 | DUF4352 domain-containing protein | - |
| IF781_RS08785 (IF781_08740) | 1823285..1823911 | + | 627 | WP_000669024.1 | hypothetical protein | - |
| IF781_RS08790 (IF781_08745) | 1823952..1824293 | + | 342 | WP_000627540.1 | DUF3969 family protein | - |
| IF781_RS08795 (IF781_08750) | 1824394..1824966 | + | 573 | WP_000414216.1 | hypothetical protein | - |
| IF781_RS08800 (IF781_08755) | 1825164..1826176 | - | 1013 | Protein_1733 | IS3 family transposase | - |
| IF781_RS08805 (IF781_08760) | 1826321..1826416 | + | 96 | WP_001801861.1 | type I toxin-antitoxin system Fst family toxin PepA1 | Toxin |
| - | 1826444..1826501 | - | 58 | - | - | Antitoxin |
| IF781_RS08810 (IF781_08765) | 1826539..1826640 | + | 102 | WP_001792025.1 | hypothetical protein | - |
| IF781_RS08815 (IF781_08770) | 1826618..1826779 | - | 162 | Protein_1736 | transposase | - |
| IF781_RS08820 (IF781_08775) | 1826764..1827174 | - | 411 | WP_001808705.1 | IS21 family transposase | - |
| IF781_RS08825 (IF781_08780) | 1827716..1828945 | - | 1230 | WP_000072627.1 | restriction endonuclease subunit S | - |
| IF781_RS08830 (IF781_08785) | 1828938..1830494 | - | 1557 | WP_031862851.1 | type I restriction-modification system subunit M | - |
| IF781_RS08835 (IF781_08790) | 1830658..1830792 | - | 135 | WP_001791797.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukD / hlgA / selk | 1820726..1853334 | 32608 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 32 a.a. Molecular weight: 3554.32 Da Isoelectric Point: 10.4449
>T174855 WP_001801861.1 NZ_CP062398:1826321-1826416 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
Download Length: 96 bp
>T174855 NZ_CP081698:293718-293993 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
Antitoxin
Download Length: 58 bp
>AT174855 NZ_CP062398:c1826501-1826444 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
