Detailed information of TA system TA174851

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 4834..5141
• Replicon: plasmid unnamed1
• Accession: NZ_CP062396
• Organism: Staphylococcus aureus strain NAS_AN_005

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: IF694_RS13475
• Protein ID: WP_072357969.1
• Coordinates: 4965..5141 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	4834..4973 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF694_RS13435 (401)	401..580	+	180	WP_000669791.1	hypothetical protein	-
IF694_RS13440 (891)	891..1151	+	261	WP_001791826.1	hypothetical protein	-
IF694_RS13445 (1203)	1203..1553	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
IF694_RS13450 (2064)	2064..2399	-	336	Protein_3	SH3 domain-containing protein	-
IF694_RS13455 (3050)	3050..3541	-	492	WP_000920038.1	staphylokinase	-
IF694_RS13460 (3732)	3732..4487	-	756	WP_000861038.1	CHAP domain-containing protein	-
IF694_RS13465 (4499)	4499..4753	-	255	WP_000611512.1	phage holin	-
IF694_RS13470 (4805)	4805..4912	+	108	WP_031762631.1	hypothetical protein	-
- (4834)	4834..4973	+	140	NuclAT_0	-	Antitoxin
- (4834)	4834..4973	+	140	NuclAT_0	-	Antitoxin
- (4834)	4834..4973	+	140	NuclAT_0	-	Antitoxin
- (4834)	4834..4973	+	140	NuclAT_0	-	Antitoxin
IF694_RS13475 (4965)	4965..5141	-	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
IF694_RS13480 (5284)	5284..5658	-	375	WP_000340977.1	hypothetical protein	-
IF694_RS13485 (5714)	5714..6001	-	288	WP_001040255.1	hypothetical protein	-
IF694_RS13490 (6048)	6048..6200	-	153	WP_000654329.1	hypothetical protein	-
IF694_RS13495 (6190)	6190..9975	-	3786	WP_240022153.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	scn / sak	1..43414	43414

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T174851 WP_072357969.1 NZ_CP062396:c5141-4965 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174851 NZ_CP081691:279874-280179 [Escherichia coli]
ATGCAATTCATCATCTACGAATATAAGCGGGTAAGCCATTACAAAATGTTTGTCGATGTGCAAAGCGATATAGTTGATAC
ACCAGGCCGTCGTATGGTTATACCGCTGATTGAATCCCATCACTTGTCTGAAATCGTAAACAGCTCCCTGTTCCCGGTAG
TCAGAATTAACGATGAAGACTACCGGGTAATGACTACCGAGCTATCAAGCGTGTCTGCGGCGGTTACTGGTGAAGCTATT
GCCGATGTCAGCTCTGATGCAGATGCGATAAAAAATGCTATCAACCTTATGTTCTGGGGAATTTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT174851 NZ_CP062396:4834-4973 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin