Detailed information of TA system TA174845

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2593976..2594255
• Replicon: chromosome
• Accession: NZ_CP062395
• Organism: Staphylococcus aureus strain NAS_AN_005

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF694_RS12650
• Protein ID: WP_001802298.1
• Coordinates: 2593976..2594080 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2594076..2594255 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF694_RS12625 (IF694_12490)	2589385..2590167	+	783	WP_000908193.1	ABC transporter ATP-binding protein	-
IF694_RS12630 (IF694_12495)	2590235..2591092	+	858	WP_000370936.1	HAD family hydrolase	-
IF694_RS12640 (IF694_12500)	2592141..2593268	+	1128	WP_047213687.1	SAP domain-containing protein	-
IF694_RS12645 (IF694_12505)	2593375..2593815	+	441	Protein_2453	recombinase family protein	-
IF694_RS12650 (IF694_12510)	2593976..2594080	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2594076..2594255	-	180	-	-	Antitoxin
IF694_RS12660 (IF694_12515)	2594586..2595677	-	1092	WP_047213685.1	hypothetical protein	-
IF694_RS12665 (IF694_12520)	2595943..2596923	-	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
IF694_RS12670 (IF694_12525)	2596925..2597245	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF694_RS12675 (IF694_12530)	2597397..2598062	+	666	WP_001024091.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174845 WP_001802298.1 NZ_CP062395:2593976-2594080 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174845 NZ_CP081690:c4256186-4255899 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT174845 NZ_CP062395:c2594255-2594076 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGTAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin