Detailed information of TA system TA174843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2336958..2337475
• Replicon: chromosome
• Accession: NZ_CP062395
• Organism: Staphylococcus aureus strain NAS_AN_005

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2S6D1N9
• Locus tag: IF694_RS11315
• Protein ID: WP_000113263.1
• Coordinates: 2337209..2337475 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: IF694_RS11310
• Protein ID: WP_000584499.1
• Coordinates: 2336958..2337209 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF694_RS11280 (IF694_11155)	2332657..2333376	+	720	WP_000479576.1	amino acid ABC transporter permease	-
IF694_RS11285 (IF694_11160)	2333373..2334104	+	732	WP_000615459.1	amino acid ABC transporter ATP-binding protein	-
IF694_RS11290 (IF694_11165)	2334201..2335451	-	1251	WP_001012216.1	FemA/FemB family glycyltransferase FmhA	-
IF694_RS11295 (IF694_11170)	2335706..2336068	+	363	WP_000819846.1	DUF4467 domain-containing protein	-
IF694_RS11300 (IF694_11175)	2336087..2336686	+	600	WP_000162805.1	DsbA family protein	-
IF694_RS11305 (IF694_11180)	2336693..2336793	+	101	Protein_2195	hypothetical protein	-
IF694_RS11310 (IF694_11185)	2336958..2337209	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF694_RS11315 (IF694_11190)	2337209..2337475	+	267	WP_000113263.1	Txe/YoeB family addiction module toxin	Toxin
IF694_RS11320 (IF694_11195)	2337768..2339315	+	1548	WP_047212937.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
IF694_RS11325 (IF694_11200)	2339501..2339968	+	468	WP_000153349.1	SRPBCC domain-containing protein	-
IF694_RS11330 (IF694_11205)	2340055..2340237	+	183	WP_000079140.1	hypothetical protein	-
IF694_RS11335 (IF694_11210)	2340440..2341264	+	825	WP_000594640.1	formate/nitrite transporter family protein	-
IF694_RS11340 (IF694_11215)	2341789..2342325	+	537	WP_000185898.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.01 Da
• Isoelectric Point: 10.1628

>T174843 WP_000113263.1 NZ_CP062395:2337209-2337475 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T174843 NZ_CP081690:3901457-3901798 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT174843 WP_000584499.1 NZ_CP062395:2336958-2337209 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT174843 NZ_CP081690:3901119-3901436 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Structures

Toxin

• AlphaFold DB: A0A2S6D1N9

Antitoxin

• AlphaFold DB: T1YB60