Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2280154..2280677 Replicon chromosome
Accession NZ_CP062395
Organism Staphylococcus aureus strain NAS_AN_005

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag IF694_RS11040 Protein ID WP_000074048.1
Coordinates 2280411..2280677 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag IF694_RS11035 Protein ID WP_000587617.1
Coordinates 2280154..2280411 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF694_RS11015 (IF694_10890) 2275233..2276426 + 1194 WP_000675402.1 MFS transporter -
IF694_RS11020 (IF694_10895) 2276650..2277399 - 750 WP_000072454.1 CPBP family lipoprotein N-acylation protein LnsB -
IF694_RS11025 (IF694_10900) 2277594..2279171 + 1578 WP_000971447.1 FMN-binding glutamate synthase family protein -
IF694_RS11030 (IF694_10905) 2279339..2279794 - 456 WP_000732082.1 DUF1307 domain-containing protein -
IF694_RS11035 (IF694_10910) 2280154..2280411 + 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF694_RS11040 (IF694_10915) 2280411..2280677 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
IF694_RS11045 (IF694_10920) 2281033..2282109 + 1077 WP_001076675.1 M42 family metallopeptidase -
IF694_RS11050 (IF694_10925) 2282454..2283116 + 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
IF694_RS11055 (IF694_10930) 2283109..2283885 + 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
IF694_RS11060 (IF694_10935) 2284280..2285467 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T174840 WP_000074048.1 NZ_CP062395:2280411-2280677 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174840 NZ_CP081690:2935014-2935121 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT174840 WP_000587617.1 NZ_CP062395:2280154-2280411 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174840 NZ_CP081690:c2934967-2934901 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References