Detailed information of TA system TA174832

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2637763..2638026
• Replicon: chromosome
• Accession: NZ_CP062393
• Organism: Staphylococcus aureus strain NAS_AN_009

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF695_RS13085
• Protein ID: WP_001802298.1
• Coordinates: 2637763..2637867 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2637862..2638026 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF695_RS13055	2633147..2633929	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
IF695_RS13060	2633997..2634854	+	858	WP_000370924.1	HAD family hydrolase	-
IF695_RS13070	2635559..2635651	-	93	WP_001790138.1	hypothetical protein	-
IF695_RS13075	2635940..2637076	+	1137	WP_000115564.1	SAP domain-containing protein	-
IF695_RS13080	2637119..2637602	+	484	Protein_2542	recombinase family protein	-
IF695_RS13085	2637763..2637867	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2637862..2638026	-	165	-	-	Antitoxin
IF695_RS13095	2638367..2639458	-	1092	WP_000495671.1	lytic regulatory protein	-
IF695_RS13100	2639724..2640704	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
IF695_RS13105	2640706..2641026	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF695_RS13110	2641178..2641843	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174832 WP_001802298.1 NZ_CP062393:2637763-2637867 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174832 NZ_CP081690:1046791-1047126 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAAGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 165 bp

>AT174832 NZ_CP062393:c2638026-2637862 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin