Detailed information of TA system TA174829

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2347432..2347616
• Replicon: chromosome
• Accession: NZ_CP062393
• Organism: Staphylococcus aureus strain NAS_AN_009

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IF695_RS11565
• Protein ID: WP_000482650.1
• Coordinates: 2347432..2347539 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2347556..2347616 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF695_RS11540	2342794..2343267	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF695_RS11545	2343390..2344601	-	1212	WP_001192076.1	multidrug effflux MFS transporter	-
IF695_RS11550	2344783..2345442	-	660	WP_000831298.1	membrane protein	-
IF695_RS11555	2345502..2346644	-	1143	WP_001176863.1	glycerate kinase	-
IF695_RS11560	2346912..2347298	+	387	WP_000779358.1	flippase GtxA	-
IF695_RS11565	2347432..2347539	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2347556..2347616	-	61	-	-	Antitoxin
IF695_RS11570	2348167..2349930	+	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
IF695_RS11575	2349955..2351688	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF695_RS11580	2351919..2352086	+	168	WP_197838684.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174829 WP_000482650.1 NZ_CP062393:2347432-2347539 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174829 NZ_CP081690:708207-708521 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174829 NZ_CP062393:c2347616-2347556 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin