Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2315593..2316116 Replicon chromosome
Accession NZ_CP062393
Organism Staphylococcus aureus strain NAS_AN_009

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag IF695_RS11425 Protein ID WP_000074048.1
Coordinates 2315850..2316116 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF695_RS11420 Protein ID WP_000587616.1
Coordinates 2315593..2315850 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF695_RS11400 (2310674) 2310674..2311867 + 1194 WP_000675401.1 MFS transporter -
IF695_RS11405 (2312091) 2312091..2312840 - 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
IF695_RS11410 (2313035) 2313035..2314612 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
IF695_RS11415 (2314780) 2314780..2315235 - 456 WP_000732082.1 DUF1307 domain-containing protein -
IF695_RS11420 (2315593) 2315593..2315850 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF695_RS11425 (2315850) 2315850..2316116 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
IF695_RS11430 (2316471) 2316471..2317547 + 1077 WP_001076671.1 M42 family metallopeptidase -
IF695_RS11435 (2317795) 2317795..2318457 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
IF695_RS11440 (2318450) 2318450..2319226 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
IF695_RS11445 (2319622) 2319622..2320809 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T174828 WP_000074048.1 NZ_CP062393:2315850-2316116 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174828 NZ_CP081690:322301-322576 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT174828 WP_000587616.1 NZ_CP062393:2315593-2315850 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174828 NZ_CP081690:322573-322932 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References