Detailed information of TA system TA174821

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20011..20349
• Replicon: chromosome
• Accession: NZ_CP062393
• Organism: Staphylococcus aureus strain NAS_AN_009

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IF695_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 20011..20187 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20175..20349 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF695_RS00085	17841..17993	+	153	WP_001000058.1	hypothetical protein	-
IF695_RS00090	18039..18326	+	288	WP_001262621.1	hypothetical protein	-
IF695_RS00095	18382..18756	+	375	WP_000340977.1	hypothetical protein	-
IF695_RS00100	19129..19902	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
IF695_RS00105	20011..20187	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	20175..20349	-	175	-	-	Antitoxin
IF695_RS00115	20399..20653	+	255	WP_000611512.1	phage holin	-
IF695_RS00120	20665..21420	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF695_RS00125	21611..22102	+	492	WP_000920038.1	staphylokinase	-
IF695_RS00130	22753..23088	+	336	Protein_26	SH3 domain-containing protein	-
IF695_RS00135	23599..23949	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
IF695_RS00140	24002..24262	-	261	WP_001791826.1	hypothetical protein	-
IF695_RS00145	24573..24752	-	180	WP_000669791.1	hypothetical protein	-
IF695_RS00150	25124..25321	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / sak / scn	1..23949	23948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T174821 WP_011447039.1 NZ_CP062393:20011-20187 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174821 NZ_CP081684:4476426-4476803 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT174821 NZ_CP062393:c20349-20175 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin