Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2623050..2623312 Replicon chromosome
Accession NZ_CP062390
Organism Staphylococcus aureus strain NAS_AN_036

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag IF699_RS12980 Protein ID WP_001802298.1
Coordinates 2623050..2623154 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2623149..2623312 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF699_RS12965 2619847..2620629 + 783 WP_000908189.1 ABC transporter ATP-binding protein -
IF699_RS12970 2620697..2621554 + 858 WP_000370928.1 HAD family hydrolase -
IF699_RS12975 2622212..2622370 - 159 WP_001792784.1 hypothetical protein -
IF699_RS12980 2623050..2623154 + 105 WP_001802298.1 hypothetical protein Toxin
- 2623149..2623312 - 164 - - Antitoxin
IF699_RS12990 2623596..2624687 - 1092 WP_000495681.1 hypothetical protein -
IF699_RS12995 2624953..2625933 - 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
IF699_RS13000 2625935..2626255 - 321 WP_000003755.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
IF699_RS13005 2626407..2627072 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T174814 WP_001802298.1 NZ_CP062390:2623050-2623154 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T174814 NZ_CP081684:2935014-2935121 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 164 bp

>AT174814 NZ_CP062390:c2623312-2623149 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References