Detailed information of TA system TA174810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2313373..2313896
• Replicon: chromosome
• Accession: NZ_CP062390
• Organism: Staphylococcus aureus strain NAS_AN_036

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IF699_RS11395
• Protein ID: WP_000074046.1
• Coordinates: 2313630..2313896 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2K4AGF2
• Locus tag: IF699_RS11390
• Protein ID: WP_000587615.1
• Coordinates: 2313373..2313630 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF699_RS11370 (2308468)	2308468..2309661	+	1194	WP_000675403.1	MFS transporter	-
IF699_RS11375 (2309885)	2309885..2310634	-	750	WP_000019956.1	CPBP family lipoprotein N-acylation protein LnsB	-
IF699_RS11380 (2310824)	2310824..2312401	+	1578	WP_000143490.1	FMN-binding glutamate synthase family protein	-
IF699_RS11385 (2312551)	2312551..2313015	-	465	WP_000736689.1	DUF1307 domain-containing protein	-
IF699_RS11390 (2313373)	2313373..2313630	+	258	WP_000587615.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF699_RS11395 (2313630)	2313630..2313896	+	267	WP_000074046.1	Txe/YoeB family addiction module toxin	Toxin
IF699_RS11400 (2314209)	2314209..2315285	+	1077	WP_001076667.1	M42 family metallopeptidase	-
IF699_RS11405 (2315533)	2315533..2316195	+	663	WP_000923528.1	ATP-binding cassette domain-containing protein	-
IF699_RS11410 (2316188)	2316188..2316961	+	774	WP_240024551.1	iron export ABC transporter permease subunit FetB	-
IF699_RS11415 (2317313)	2317313..2318497	+	1185	WP_000115415.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10658.27 Da
• Isoelectric Point: 10.1384

>T174810 WP_000074046.1 NZ_CP062390:2313630-2313896 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKPFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T174810 NZ_CP081684:1968763-1969017 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9746.68 Da
• Isoelectric Point: 4.1111

>AT174810 WP_000587615.1 NZ_CP062390:2313373-2313630 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT174810 NZ_CP081684:1968515-1968766 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2K4AGF2