Detailed information of TA system TA174797

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2585883..2586161
• Replicon: chromosome
• Accession: NZ_CP062388
• Organism: Staphylococcus aureus strain NAS_AN_044

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF700_RS12720
• Protein ID: WP_001802298.1
• Coordinates: 2585883..2585987 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2585983..2586161 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF700_RS12705	2582680..2583462	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
IF700_RS12710	2583530..2584387	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
IF700_RS12715	2585045..2585203	-	159	WP_001792784.1	hypothetical protein	-
IF700_RS12720	2585883..2585987	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2585983..2586161	-	179	-	-	Antitoxin
IF700_RS12730	2586420..2587511	-	1092	WP_000495669.1	hypothetical protein	-
IF700_RS12735	2587777..2588754	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
IF700_RS12740	2588756..2589076	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF700_RS12745	2589228..2589893	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174797 WP_001802298.1 NZ_CP062388:2585883-2585987 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174797 NZ_CP081678:c6759-6475 [Escherichia coli]
GTGTATAAACTCACTGAACGGGCAGCAGACGACTTCGCCGGGATTTATGACTATACGCTCTTGAAATTTGGTGAAGCTCA
GGCAGACCATTATACAGACGCACTTGAGGCATTTTTCGAGACACTGGCCGGAATGCCAGATATGGGACGTGACTACCATA
CCGTTCCTGGTGTGATGCGCATTGAATTTCAGCGACATGCCATTTTTTATACGGTTCGTGATACGGATATTCTGATTGCG
CGTATTTTGCACCAACAGATGAACCATAAACGCCATTTACTGTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT174797 NZ_CP062388:c2586161-2585983 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin