Detailed information of TA system TA174795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2319932..2320449
• Replicon: chromosome
• Accession: NZ_CP062388
• Organism: Staphylococcus aureus strain NAS_AN_044

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: IF700_RS11325
• Protein ID: WP_000113265.1
• Coordinates: 2320183..2320449 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: IF700_RS11320
• Protein ID: WP_000584499.1
• Coordinates: 2319932..2320183 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF700_RS11290 (2315630)	2315630..2316349	+	720	WP_000479576.1	amino acid ABC transporter permease	-
IF700_RS11295 (2316346)	2316346..2317077	+	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
IF700_RS11300 (2317174)	2317174..2318424	-	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
IF700_RS11305 (2318679)	2318679..2319041	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
IF700_RS11310 (2319060)	2319060..2319659	+	600	WP_000162810.1	DsbA family protein	-
IF700_RS11315 (2319687)	2319687..2319767	+	81	WP_223197974.1	hypothetical protein	-
IF700_RS11320 (2319932)	2319932..2320183	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF700_RS11325 (2320183)	2320183..2320449	+	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
IF700_RS11330 (2320484)	2320484..2320555	+	72	Protein_2200	hypothetical protein	-
IF700_RS11335 (2320744)	2320744..2322291	+	1548	WP_000727772.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
IF700_RS11340 (2322478)	2322478..2322945	+	468	WP_000153347.1	SRPBCC domain-containing protein	-
IF700_RS11345 (2323029)	2323029..2323211	+	183	WP_000230292.1	hypothetical protein	-
IF700_RS11350 (2323428)	2323428..2324252	+	825	WP_000572038.1	formate/nitrite transporter family protein	-
IF700_RS11355 (2324486)	2324486..2325022	+	537	WP_000169317.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T174795 WP_000113265.1 NZ_CP062388:2320183-2320449 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T174795 NZ_CP081677:c4488201-4488028 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT174795 WP_000584499.1 NZ_CP062388:2319932-2320183 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT174795 NZ_CP081677:c4488525-4488229 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• PDB: 7BWF

Antitoxin

• AlphaFold DB: T1YB60