Detailed information of TA system TA174793

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2294907..2295091
• Replicon: chromosome
• Accession: NZ_CP062388
• Organism: Staphylococcus aureus strain NAS_AN_044

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: IF700_RS11190
• Protein ID: WP_000482652.1
• Coordinates: 2294907..2295014 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2295031..2295091 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF700_RS11165	2290269..2290742	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
IF700_RS11170	2290865..2292076	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF700_RS11175	2292258..2292917	-	660	WP_000831298.1	membrane protein	-
IF700_RS11180	2292977..2294119	-	1143	WP_001176863.1	glycerate kinase	-
IF700_RS11185	2294387..2294773	+	387	WP_000779360.1	flippase GtxA	-
IF700_RS11190	2294907..2295014	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2295031..2295091	-	61	-	-	Antitoxin
IF700_RS11195	2295717..2297480	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
IF700_RS11200	2297505..2299238	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
IF700_RS11205	2299505..2299636	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174793 WP_000482652.1 NZ_CP062388:2294907-2295014 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174793 NZ_CP081677:c4337696-4337346 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174793 NZ_CP062388:c2295091-2295031 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin