Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2742183..2742597 | Replicon | chromosome |
| Accession | NZ_CP062386 | ||
| Organism | Staphylococcus aureus strain NAS_AN_047 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | IF701_RS13525 | Protein ID | WP_001065046.1 |
| Coordinates | 2742183..2742434 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | IF701_RS13530 | Protein ID | WP_000028424.1 |
| Coordinates | 2742424..2742597 (+) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF701_RS13485 (2737840) | 2737840..2738760 | + | 921 | WP_000138475.1 | recombinase RecT | - |
| IF701_RS13490 (2738841) | 2738841..2739458 | + | 618 | WP_072353921.1 | MBL fold metallo-hydrolase | - |
| IF701_RS13495 (2739459) | 2739459..2739929 | + | 471 | WP_000934762.1 | single-stranded DNA-binding protein | - |
| IF701_RS13500 (2739959) | 2739959..2740852 | + | 894 | WP_000148327.1 | DnaD domain-containing protein | - |
| IF701_RS13505 (2740859) | 2740859..2741077 | + | 219 | WP_000338527.1 | hypothetical protein | - |
| IF701_RS13510 (2741086) | 2741086..2741541 | + | 456 | WP_000401965.1 | RusA family crossover junction endodeoxyribonuclease | - |
| IF701_RS13515 (2741554) | 2741554..2741922 | + | 369 | WP_000101270.1 | SA1788 family PVL leukocidin-associated protein | - |
| IF701_RS13520 (2741926) | 2741926..2742168 | + | 243 | WP_000131381.1 | phi PVL orf 51-like protein | - |
| IF701_RS13525 (2742183) | 2742183..2742434 | + | 252 | WP_001065046.1 | DUF1024 family protein | Toxin |
| IF701_RS13530 (2742424) | 2742424..2742597 | + | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| IF701_RS13535 (2742626) | 2742626..2742880 | + | 255 | WP_223297745.1 | hypothetical protein | - |
| IF701_RS13540 (2742881) | 2742881..2743042 | + | 162 | WP_000889682.1 | hypothetical protein | - |
| IF701_RS13545 (2743057) | 2743057..2743590 | + | 534 | WP_001061838.1 | dUTPase | - |
| IF701_RS13550 (2743627) | 2743627..2743872 | + | 246 | WP_001282074.1 | hypothetical protein | - |
| IF701_RS13555 (2743869) | 2743869..2744075 | + | 207 | WP_000195803.1 | DUF1381 domain-containing protein | - |
| IF701_RS13560 (2744072) | 2744072..2744458 | + | 387 | WP_000592201.1 | hypothetical protein | - |
| IF701_RS13565 (2744455) | 2744455..2744604 | + | 150 | WP_000595305.1 | transcriptional activator RinB | - |
| IF701_RS13570 (2744763) | 2744763..2745413 | + | 651 | WP_001005262.1 | hypothetical protein | - |
| IF701_RS13575 (2745413) | 2745413..2745613 | + | 201 | WP_000265041.1 | DUF1514 family protein | - |
| IF701_RS13580 (2745636) | 2745636..2746106 | + | 471 | WP_000282758.1 | hypothetical protein | - |
| IF701_RS13585 (2746221) | 2746221..2746673 | + | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| IF701_RS13590 (2746689) | 2746689..2747033 | + | 345 | WP_000817289.1 | HNH endonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | hlb | 2725853..2747628 | 21775 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9377.26 Da Isoelectric Point: 3.7128
>T174784 WP_001065046.1 NZ_CP062386:2742183-2742434 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T174784 NZ_CP081677:2241996-2242099 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT174784 WP_000028424.1 NZ_CP062386:2742424-2742597 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT174784 NZ_CP081677:c2242137-2241866 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|