Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2336285..2336802 Replicon chromosome
Accession NZ_CP062386
Organism Staphylococcus aureus strain NAS_AN_047

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF701_RS11370 Protein ID WP_000113262.1
Coordinates 2336536..2336802 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF701_RS11365 Protein ID WP_000584499.1
Coordinates 2336285..2336536 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF701_RS11335 (2331983) 2331983..2332702 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF701_RS11340 (2332699) 2332699..2333430 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF701_RS11345 (2333527) 2333527..2334777 - 1251 WP_001012228.1 FemA/FemB family glycyltransferase FmhA -
IF701_RS11350 (2335032) 2335032..2335394 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF701_RS11355 (2335413) 2335413..2336012 + 600 WP_000162803.1 DsbA family protein -
IF701_RS11360 (2336040) 2336040..2336120 + 81 WP_223197974.1 hypothetical protein -
IF701_RS11365 (2336285) 2336285..2336536 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF701_RS11370 (2336536) 2336536..2336802 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF701_RS11375 (2336837) 2336837..2336908 + 72 WP_223200558.1 hypothetical protein -
IF701_RS11380 (2337096) 2337096..2338646 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF701_RS11385 (2338832) 2338832..2339299 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF701_RS11390 (2339386) 2339386..2339568 + 183 WP_000079142.1 hypothetical protein -
IF701_RS11395 (2339785) 2339785..2340609 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF701_RS11400 (2340843) 2340843..2341379 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174777 WP_000113262.1 NZ_CP062386:2336536-2336802 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174777 NZ_CP081677:775346-775642 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT174777 WP_000584499.1 NZ_CP062386:2336285-2336536 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174777 NZ_CP081677:775644-776039 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References