Detailed information of TA system TA174775

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2311246..2311430
• Replicon: chromosome
• Accession: NZ_CP062386
• Organism: Staphylococcus aureus strain NAS_AN_047

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IF701_RS11235
• Protein ID: WP_000482650.1
• Coordinates: 2311246..2311353 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2311370..2311430 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF701_RS11210	2306618..2307091	+	474	WP_240022482.1	GyrI-like domain-containing protein	-
IF701_RS11215	2307214..2308425	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF701_RS11220	2308607..2309266	-	660	WP_000831298.1	membrane protein	-
IF701_RS11225	2309326..2310468	-	1143	WP_001176863.1	glycerate kinase	-
IF701_RS11230	2310726..2311112	+	387	WP_000779358.1	flippase GtxA	-
IF701_RS11235	2311246..2311353	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2311370..2311430	-	61	-	-	Antitoxin
IF701_RS11240	2312001..2313764	+	1764	WP_001064820.1	ABC transporter ATP-binding protein	-
IF701_RS11245	2313789..2315522	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF701_RS11250	2315753..2315920	+	168	WP_001792506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174775 WP_000482650.1 NZ_CP062386:2311246-2311353 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174775 NZ_CP081677:322301-322576 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174775 NZ_CP062386:c2311430-2311370 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin