Detailed information of TA system TA174774

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2279725..2280248
• Replicon: chromosome
• Accession: NZ_CP062386
• Organism: Staphylococcus aureus strain NAS_AN_047

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: IF701_RS11095
• Protein ID: WP_000074043.1
• Coordinates: 2279982..2280248 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: IF701_RS11090
• Protein ID: WP_000587618.1
• Coordinates: 2279725..2279982 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF701_RS11075 (2276221)	2276221..2276970	-	750	WP_000072441.1	CPBP family lipoprotein N-acylation protein LnsB	-
IF701_RS11080 (2277165)	2277165..2278742	+	1578	WP_000143508.1	FMN-binding glutamate synthase family protein	-
IF701_RS11085 (2278910)	2278910..2279365	-	456	WP_000732082.1	DUF1307 domain-containing protein	-
IF701_RS11090 (2279725)	2279725..2279982	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF701_RS11095 (2279982)	2279982..2280248	+	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
IF701_RS11100 (2280604)	2280604..2281680	+	1077	WP_001076665.1	M42 family metallopeptidase	-
IF701_RS11105 (2281928)	2281928..2282590	+	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
IF701_RS11110 (2282583)	2282583..2283359	+	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
IF701_RS11115 (2283755)	2283755..2284942	+	1188	WP_000026187.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T174774 WP_000074043.1 NZ_CP062386:2279982-2280248 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T174774 NZ_CP081675:c31499-31221 [Mycolicibacterium farcinogenes]
GTGAGCAACGACCAGCCATGGGCGGTCCGACTGGCGCCCAGCGCGGTCCGGGCACTGGATCGACTTCCGCACAAAGTGGC
GGCCGCGATCGTGGAGTTCATCACCGCAACACTGCCCACCGACCCATACCGGATGTCGAAGCCGCTCCGTCACGAGCTGG
AGGGCTGGCGAGTCGCACGACGCGGCGACTATCGCGTCACCTTCCGCATACTCGACGACGCCCACGCCCTCCTGATCGGC
CGTGTCGAGCACCGGGCACACATCTACCGCCCCAGCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT174774 WP_000587618.1 NZ_CP062386:2279725-2279982 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT174774 NZ_CP081675:c31765-31496 [Mycolicibacterium farcinogenes]
ATGAAGACGGTACCGCTCAGCGAGGCCAAGGACAAGCTTTCAGCGTTGGTCGACGAGGCCGACAGCACGCACGAGATCAT
CCGGATCACCCGGCACGGGCGTGCCGCCGCGGTCTTGATGTCTGCCGACGATCTGGACTCACTCAATGAAACCCTGCATG
CTTTACGGACCCCAGGGCTCGTCGACGAACTCAACCAGGCAGACGCCGACTACGCCGCCGGCAAGACCATCACCGGTGAA
GATCTGCGTAAACGCTACGGTCTGTCGTGA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2