Detailed information of TA system TA174763

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2287881..2288065
• Replicon: chromosome
• Accession: NZ_CP062384
• Organism: Staphylococcus aureus strain NAS_AN_050

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF702_RS11145
• Protein ID: WP_000482647.1
• Coordinates: 2287881..2287988 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2288005..2288065 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF702_RS11120	2283245..2283718	+	474	WP_240023954.1	GyrI-like domain-containing protein	-
IF702_RS11125	2283841..2285052	-	1212	WP_001191975.1	multidrug effflux MFS transporter	-
IF702_RS11130	2285232..2285891	-	660	WP_000831298.1	membrane protein	-
IF702_RS11135	2285951..2287093	-	1143	WP_001176860.1	glycerate kinase	-
IF702_RS11140	2287361..2287747	+	387	WP_000779354.1	flippase GtxA	-
IF702_RS11145	2287881..2287988	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2288005..2288065	-	61	-	-	Antitoxin
IF702_RS11150	2288015..2288182	+	168	WP_000301894.1	hypothetical protein	-
IF702_RS11155	2288560..2290299	+	1740	WP_001064831.1	ABC transporter ATP-binding protein	-
IF702_RS11160	2290348..2292081	+	1734	WP_000488492.1	ABC transporter ATP-binding protein	-
IF702_RS11165	2292312..2292479	+	168	WP_031785511.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174763 WP_000482647.1 NZ_CP062384:2287881-2287988 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174763 NZ_CP081505:c2482416-2482108 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGACAACCAGGATCAGGGAAAACTAGTTTGCGCTCGGCAATTT
CCGAAGAAACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACATGCAACATCCTATTCTAATCAGCTGGTAAAGCTTAATTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT174763 NZ_CP062384:c2288065-2288005 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin