Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 20057..20395 Replicon chromosome
Accession NZ_CP062384
Organism Staphylococcus aureus strain NAS_AN_050

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag IF702_RS00110 Protein ID WP_011447039.1
Coordinates 20057..20233 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 20221..20395 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF702_RS00090 17841..17993 + 153 WP_001153681.1 hypothetical protein -
IF702_RS00095 18148..19277 + 1130 WP_098686295.1 IS3 family transposase -
IF702_RS00100 19281..19553 + 273 WP_064138970.1 hypothetical protein -
IF702_RS00105 19611..19907 + 297 WP_000539688.1 DUF2951 domain-containing protein -
IF702_RS00110 20057..20233 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 20221..20395 - 175 - - Antitoxin
IF702_RS00120 20445..20699 + 255 WP_000611512.1 phage holin -
IF702_RS00125 20711..21466 + 756 WP_000861038.1 CHAP domain-containing protein -
IF702_RS00130 21657..22148 + 492 WP_000919350.1 staphylokinase -
IF702_RS00135 22798..23133 + 336 Protein_26 SH3 domain-containing protein -
IF702_RS00140 23228..23677 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
IF702_RS00145 24362..24712 + 351 WP_000702263.1 complement inhibitor SCIN-A -
IF702_RS00150 24765..25025 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / chp / scn 1..24712 24711
- flank IS/Tn - - 18148..18429 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(30-58)


Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T174756 WP_011447039.1 NZ_CP062384:20057-20233 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T174756 NZ_CP081490:c6336627-6336331 [Pseudomonas protegens]
ATGCACATCATCACCGCAAAACGGATCCGGCAGGCCAAGGAGCAATGGCCGCAAGTCGCGCGGGCGCTGGATACCTGGTA
CCGCAAGGCCAAAGGCGCCAGGCCGGCTGATTTCGCCGACATGAAGGCCTTGTTCCCGGCGCTAGACAAGGTCGGGCGCT
TTCATGTTTTCGACATTGGCGGCAACAAACTGAGGCTGATCGCAATCGTGCGCTATGGGGGGCAGCGCCTCTATATCAGG
CATGTGCTGGATCACGGCGAATACGACAAGGGGCTGTGGAAGGAGGAGTCACAATGA

Antitoxin


Download         Length: 175 bp

>AT174756 NZ_CP062384:c20395-20221 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7NS1


Antitoxin

Download structure file

References