Detailed information of TA system TA174750

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2712107..2712370
• Replicon: chromosome
• Accession: NZ_CP062382
• Organism: Staphylococcus aureus strain NAS_AN_068

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF703_RS13535
• Protein ID: WP_001802298.1
• Coordinates: 2712107..2712211 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2712206..2712370 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF703_RS13510	2707516..2708298	+	783	WP_000908193.1	ABC transporter ATP-binding protein	-
IF703_RS13515	2708366..2709223	+	858	WP_000370936.1	HAD family hydrolase	-
IF703_RS13525	2710272..2711399	+	1128	WP_047213687.1	SAP domain-containing protein	-
IF703_RS13530	2711506..2711946	+	441	Protein_2630	recombinase family protein	-
IF703_RS13535	2712107..2712211	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2712206..2712370	-	165	-	-	Antitoxin
IF703_RS13545	2712717..2713808	-	1092	WP_047213685.1	hypothetical protein	-
IF703_RS13550	2714074..2715054	-	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
IF703_RS13555	2715056..2715376	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF703_RS13560	2715528..2716193	+	666	WP_001024091.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174750 WP_001802298.1 NZ_CP062382:2712107-2712211 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174750 NZ_CP081490:1286878-1287276 [Pseudomonas protegens]
ATGCTCAAGTACATGCTGGATACCAACATCTGCATCTTTACCATCAAGAACAAGCCTGAACAGGTTCGCGAGGCATTCAG
GCGTCATCAGGGGCGTTTGTGCATCAGCACCATCACCTTGATGGAGCTGATTTACGGTGCGGAAAAATCTGCCATTCCGG
AGAAGAATCTCAGCCGCGTCGAGAGTTTTGTGGCGCGGTTACAGGTGCTTGATTATGACGATGCCGCCGCCATCCATAGC
GGGCAATTGCATGCTGAGCTGGTGCGACAGGGCAAGCAGATAGGTCCTTACGATCAATTGATAGCTGGCCACGCTCGATC
TTTGGGGTTGACGCTGATTACCAACAACCTTCGGGAATTTGAACGTGTTCCTGGCTTGCGGGTTGAGGATTGGGTCTAG

Antitoxin

Nucleotide

• Length: 165 bp

>AT174750 NZ_CP062382:c2712370-2712206 [Staphylococcus aureus]
GTAGTAAGTAGAAGTAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin