Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2382178..2382701 Replicon chromosome
Accession NZ_CP062382
Organism Staphylococcus aureus strain NAS_AN_068

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag IF703_RS11850 Protein ID WP_000074048.1
Coordinates 2382435..2382701 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag IF703_RS11845 Protein ID WP_000587617.1
Coordinates 2382178..2382435 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF703_RS11825 (2377257) 2377257..2378450 + 1194 WP_000675402.1 MFS transporter -
IF703_RS11830 (2378674) 2378674..2379423 - 750 WP_000072454.1 CPBP family lipoprotein N-acylation protein LnsB -
IF703_RS11835 (2379618) 2379618..2381195 + 1578 WP_000971447.1 FMN-binding glutamate synthase family protein -
IF703_RS11840 (2381363) 2381363..2381818 - 456 WP_000732082.1 DUF1307 domain-containing protein -
IF703_RS11845 (2382178) 2382178..2382435 + 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF703_RS11850 (2382435) 2382435..2382701 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
IF703_RS11855 (2383057) 2383057..2384133 + 1077 WP_001076675.1 M42 family metallopeptidase -
IF703_RS11860 (2384478) 2384478..2385140 + 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
IF703_RS11865 (2385133) 2385133..2385909 + 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
IF703_RS11870 (2386304) 2386304..2387491 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T174747 WP_000074048.1 NZ_CP062382:2382435-2382701 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174747 NZ_CP081489:c4487763-4487656 [Escherichia coli BL21(DE3)]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT174747 WP_000587617.1 NZ_CP062382:2382178-2382435 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174747 NZ_CP081489:4487810-4487876 [Escherichia coli BL21(DE3)]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References