Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1270099..1270522 Replicon chromosome
Accession NZ_CP062382
Organism Staphylococcus aureus strain NAS_AN_068

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IF703_RS06470 Protein ID WP_240024705.1
Coordinates 1270271..1270522 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IF703_RS06465 Protein ID WP_086097840.1
Coordinates 1270099..1270281 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF703_RS06420 (1266178) 1266178..1267401 - 1224 WP_001037578.1 PBSX family phage terminase large subunit -
IF703_RS06425 (1267394) 1267394..1267888 - 495 WP_000594089.1 terminase small subunit -
IF703_RS06430 (1268249) 1268249..1268650 - 402 WP_048523469.1 hypothetical protein -
IF703_RS06435 (1268651) 1268651..1268824 - 174 WP_000595257.1 transcriptional activator RinB -
IF703_RS06440 (1268817) 1268817..1269053 - 237 WP_216817969.1 hypothetical protein -
IF703_RS06445 (1269046) 1269046..1269249 - 204 WP_240024704.1 hypothetical protein -
IF703_RS06450 (1269246) 1269246..1269440 - 195 WP_216817968.1 hypothetical protein -
IF703_RS06455 (1269437) 1269437..1269520 - 84 Protein_1248 DUF1381 domain-containing protein -
IF703_RS06460 (1269570) 1269570..1270106 - 537 WP_000185680.1 dUTPase -
IF703_RS06465 (1270099) 1270099..1270281 - 183 WP_086097840.1 hypothetical protein Antitoxin
IF703_RS06470 (1270271) 1270271..1270522 - 252 WP_240024705.1 DUF1024 family protein Toxin
IF703_RS06475 (1270515) 1270515..1270682 - 168 WP_001813803.1 hypothetical protein -
IF703_RS06480 (1270694) 1270694..1270936 - 243 WP_000131381.1 phi PVL orf 51-like protein -
IF703_RS06485 (1270940) 1270940..1271308 - 369 WP_001140281.1 SA1788 family PVL leukocidin-associated protein -
IF703_RS06490 (1271309) 1271309..1271494 - 186 WP_001187254.1 DUF3113 family protein -
IF703_RS06495 (1271494) 1271494..1271901 - 408 WP_000401952.1 RusA family crossover junction endodeoxyribonuclease -
IF703_RS06500 (1271911) 1271911..1272132 - 222 WP_001123681.1 DUF3269 family protein -
IF703_RS06505 (1272146) 1272146..1272304 - 159 WP_031927495.1 hypothetical protein -
IF703_RS06510 (1272298) 1272298..1273077 - 780 WP_000803062.1 ATP-binding protein -
IF703_RS06515 (1273087) 1273087..1273857 - 771 WP_001566734.1 conserved phage C-terminal domain-containing protein -
IF703_RS06520 (1273923) 1273923..1274204 + 282 WP_000414755.1 hypothetical protein -
IF703_RS06525 (1274197) 1274197..1274346 - 150 WP_001081076.1 hypothetical protein -
IF703_RS06530 (1274343) 1274343..1275014 - 672 WP_240024706.1 putative HNHc nuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1237197..1287049 49852


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9528.43 Da        Isoelectric Point: 3.6767

>T174745 WP_240024705.1 NZ_CP062382:c1270522-1270271 [Staphylococcus aureus]
MDNREQIEQSIISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTSQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T174745 NZ_CP081489:4351085-4351342 [Escherichia coli BL21(DE3)]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6793.71 Da        Isoelectric Point: 4.4421

>AT174745 WP_086097840.1 NZ_CP062382:c1270281-1270099 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDIHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT174745 NZ_CP081489:4351354-4351899 [Escherichia coli BL21(DE3)]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References