Detailed information of TA system TA174742

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 516005..516584
• Replicon: chromosome
• Accession: NZ_CP062382
• Organism: Staphylococcus aureus strain NAS_AN_068

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: IF703_RS02775
• Protein ID: WP_001025401.1
• Coordinates: 516005..516250 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	516219..516584 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF703_RS02725 (512256)	512256..512870	+	615	WP_000191466.1	hypothetical protein	-
IF703_RS02730 (512867)	512867..513013	-	147	WP_001795334.1	hypothetical protein	-
IF703_RS02735 (513049)	513049..513231	-	183	WP_000705240.1	hypothetical protein	-
IF703_RS02740 (513301)	513301..514032	-	732	WP_000511090.1	XRE family transcriptional regulator	-
IF703_RS02745 (514184)	514184..514396	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
IF703_RS02750 (514444)	514444..514887	+	444	WP_000435357.1	hypothetical protein	-
IF703_RS02755 (514902)	514902..515051	+	150	WP_000771849.1	hypothetical protein	-
IF703_RS02760 (515092)	515092..515304	-	213	WP_000362644.1	hypothetical protein	-
IF703_RS02765 (515374)	515374..515571	+	198	WP_001148860.1	hypothetical protein	-
IF703_RS02770 (515558)	515558..515938	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
IF703_RS02775 (516005)	516005..516250	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
IF703_RS02780 (516219)	516219..516584	-	366	WP_001128433.1	hypothetical protein	Antitoxin
IF703_RS02785 (516639)	516639..516854	+	216	WP_001097552.1	hypothetical protein	-
IF703_RS02790 (516879)	516879..517142	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
IF703_RS02795 (517155)	517155..517316	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
IF703_RS02800 (517395)	517395..517718	+	324	WP_000174998.1	hypothetical protein	-
IF703_RS02805 (517733)	517733..518095	+	363	WP_000985972.1	hypothetical protein	-
IF703_RS02810 (518092)	518092..519258	+	1167	WP_000762527.1	DUF2800 domain-containing protein	-
IF703_RS02815 (519285)	519285..519842	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T174742 WP_001025401.1 NZ_CP062382:516005-516250 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T174742 NZ_CP081489:3866373-3866549 [Escherichia coli BL21(DE3)]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT174742 NZ_CP062382:c516584-516219 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin