Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 19379..19717 Replicon chromosome
Accession NZ_CP062382
Organism Staphylococcus aureus strain NAS_AN_068

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag IF703_RS00100 Protein ID WP_072353918.1
Coordinates 19379..19555 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 19543..19717 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF703_RS00080 14546..18328 + 3783 WP_240024670.1 phage tail spike protein -
IF703_RS00085 18321..18473 + 153 WP_001000058.1 hypothetical protein -
IF703_RS00090 18519..18806 + 288 WP_001262620.1 hypothetical protein -
IF703_RS00095 18862..19236 + 375 WP_000340977.1 hypothetical protein -
IF703_RS00100 19379..19555 + 177 WP_072353918.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 19543..19717 - 175 - - Antitoxin
IF703_RS00110 19767..20021 + 255 WP_000611512.1 phage holin -
IF703_RS00115 20033..20788 + 756 WP_000861038.1 CHAP domain-containing protein -
IF703_RS00120 20961..21452 + 492 WP_000920041.1 staphylokinase -
IF703_RS00125 22104..22439 + 336 Protein_24 SH3 domain-containing protein -
IF703_RS00130 22949..23299 + 351 WP_000702262.1 complement inhibitor SCIN-A -
IF703_RS00135 23352..23612 - 261 WP_001791826.1 hypothetical protein -
IF703_RS00140 23923..24102 - 180 WP_000669789.1 hypothetical protein -
IF703_RS00145 24474..24671 - 198 WP_000239610.1 phospholipase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / scn / hlb / map 1..26801 26800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(30-58)


Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6810.43 Da        Isoelectric Point: 9.9479

>T174738 WP_072353918.1 NZ_CP062382:19379-19555 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T174738 NZ_CP081489:c3029681-3029463 [Escherichia coli BL21(DE3)]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 175 bp

>AT174738 NZ_CP062382:c19717-19543 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References