Detailed information of TA system TA174732

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2661826..2662105
• Replicon: chromosome
• Accession: NZ_CP062380
• Organism: Staphylococcus aureus strain NAS_AN_076

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF704_RS13140
• Protein ID: WP_001802298.1
• Coordinates: 2661826..2661930 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2661926..2662105 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF704_RS13115	2657235..2658017	+	783	WP_000908193.1	ABC transporter ATP-binding protein	-
IF704_RS13120	2658085..2658942	+	858	WP_000370936.1	HAD family hydrolase	-
IF704_RS13130	2659991..2661118	+	1128	WP_047213687.1	SAP domain-containing protein	-
IF704_RS13135	2661225..2661665	+	441	Protein_2550	recombinase family protein	-
IF704_RS13140	2661826..2661930	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2661926..2662105	-	180	-	-	Antitoxin
IF704_RS13150	2662436..2663527	-	1092	WP_047213685.1	hypothetical protein	-
IF704_RS13155	2663793..2664773	-	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
IF704_RS13160	2664775..2665095	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF704_RS13165	2665247..2665912	+	666	WP_001024091.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174732 WP_001802298.1 NZ_CP062380:2661826-2661930 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174732 NZ_CP081489:c77977-77681 [Escherichia coli BL21(DE3)]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT174732 NZ_CP062380:c2662105-2661926 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGTAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin