Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2404808..2405325 | Replicon | chromosome |
| Accession | NZ_CP062380 | ||
| Organism | Staphylococcus aureus strain NAS_AN_076 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A2S6D1N9 |
| Locus tag | IF704_RS11805 | Protein ID | WP_000113263.1 |
| Coordinates | 2405059..2405325 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | IF704_RS11800 | Protein ID | WP_000584499.1 |
| Coordinates | 2404808..2405059 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF704_RS11770 (2400507) | 2400507..2401226 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| IF704_RS11775 (2401223) | 2401223..2401954 | + | 732 | WP_000615459.1 | amino acid ABC transporter ATP-binding protein | - |
| IF704_RS11780 (2402051) | 2402051..2403301 | - | 1251 | WP_001012216.1 | FemA/FemB family glycyltransferase FmhA | - |
| IF704_RS11785 (2403556) | 2403556..2403918 | + | 363 | WP_000819846.1 | DUF4467 domain-containing protein | - |
| IF704_RS11790 (2403937) | 2403937..2404536 | + | 600 | WP_000162805.1 | DsbA family protein | - |
| IF704_RS11795 (2404543) | 2404543..2404643 | + | 101 | Protein_2292 | hypothetical protein | - |
| IF704_RS11800 (2404808) | 2404808..2405059 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IF704_RS11805 (2405059) | 2405059..2405325 | + | 267 | WP_000113263.1 | Txe/YoeB family addiction module toxin | Toxin |
| IF704_RS11810 (2405618) | 2405618..2407165 | + | 1548 | WP_047212937.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IF704_RS11815 (2407351) | 2407351..2407818 | + | 468 | WP_000153349.1 | SRPBCC domain-containing protein | - |
| IF704_RS11820 (2407905) | 2407905..2408087 | + | 183 | WP_000079140.1 | hypothetical protein | - |
| IF704_RS11825 (2408290) | 2408290..2409114 | + | 825 | WP_000594640.1 | formate/nitrite transporter family protein | - |
| IF704_RS11830 (2409639) | 2409639..2410175 | + | 537 | WP_000185898.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.01 Da Isoelectric Point: 10.1628
>T174730 WP_000113263.1 NZ_CP062380:2405059-2405325 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T174730 NZ_CP081488:485082-485432 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT174730 WP_000584499.1 NZ_CP062380:2404808-2405059 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT174730 NZ_CP081488:484795-485076 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|