Detailed information of TA system TA174730

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2404808..2405325
• Replicon: chromosome
• Accession: NZ_CP062380
• Organism: Staphylococcus aureus strain NAS_AN_076

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2S6D1N9
• Locus tag: IF704_RS11805
• Protein ID: WP_000113263.1
• Coordinates: 2405059..2405325 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: IF704_RS11800
• Protein ID: WP_000584499.1
• Coordinates: 2404808..2405059 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF704_RS11770 (2400507)	2400507..2401226	+	720	WP_000479576.1	amino acid ABC transporter permease	-
IF704_RS11775 (2401223)	2401223..2401954	+	732	WP_000615459.1	amino acid ABC transporter ATP-binding protein	-
IF704_RS11780 (2402051)	2402051..2403301	-	1251	WP_001012216.1	FemA/FemB family glycyltransferase FmhA	-
IF704_RS11785 (2403556)	2403556..2403918	+	363	WP_000819846.1	DUF4467 domain-containing protein	-
IF704_RS11790 (2403937)	2403937..2404536	+	600	WP_000162805.1	DsbA family protein	-
IF704_RS11795 (2404543)	2404543..2404643	+	101	Protein_2292	hypothetical protein	-
IF704_RS11800 (2404808)	2404808..2405059	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF704_RS11805 (2405059)	2405059..2405325	+	267	WP_000113263.1	Txe/YoeB family addiction module toxin	Toxin
IF704_RS11810 (2405618)	2405618..2407165	+	1548	WP_047212937.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
IF704_RS11815 (2407351)	2407351..2407818	+	468	WP_000153349.1	SRPBCC domain-containing protein	-
IF704_RS11820 (2407905)	2407905..2408087	+	183	WP_000079140.1	hypothetical protein	-
IF704_RS11825 (2408290)	2408290..2409114	+	825	WP_000594640.1	formate/nitrite transporter family protein	-
IF704_RS11830 (2409639)	2409639..2410175	+	537	WP_000185898.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.01 Da
• Isoelectric Point: 10.1628

>T174730 WP_000113263.1 NZ_CP062380:2405059-2405325 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T174730 NZ_CP081488:485082-485432 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT174730 WP_000584499.1 NZ_CP062380:2404808-2405059 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT174730 NZ_CP081488:484795-485076 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Toxin

• AlphaFold DB: A0A2S6D1N9

Antitoxin

• AlphaFold DB: T1YB60