Detailed information of TA system TA174728

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2379843..2380027
• Replicon: chromosome
• Accession: NZ_CP062380
• Organism: Staphylococcus aureus strain NAS_AN_076

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF704_RS11670
• Protein ID: WP_000482647.1
• Coordinates: 2379843..2379950 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2379967..2380027 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF704_RS11645	2375205..2375678	+	474	WP_000456493.1	GyrI-like domain-containing protein	-
IF704_RS11650	2375801..2377012	-	1212	WP_001191927.1	multidrug effflux MFS transporter	-
IF704_RS11655	2377194..2377853	-	660	WP_031927729.1	membrane protein	-
IF704_RS11660	2377913..2379055	-	1143	WP_001176870.1	glycerate kinase	-
IF704_RS11665	2379323..2379709	+	387	WP_000779353.1	flippase GtxA	-
IF704_RS11670	2379843..2379950	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2379967..2380027	-	61	-	-	Antitoxin
IF704_RS11675	2380654..2382417	+	1764	WP_031927727.1	ABC transporter ATP-binding protein	-
IF704_RS11680	2382442..2384175	+	1734	WP_000486497.1	ABC transporter ATP-binding protein	-
IF704_RS11685	2384406..2384573	+	168	WP_031927726.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174728 WP_000482647.1 NZ_CP062380:2379843-2379950 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174728 NZ_CP081486:47085-47399 [Pasteurella multocida]
ATGCTCGATATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAGGATTTGTCGGCTAAGGCGGCTATTCT
TGCTCGTATTAGTCGTGCTAAAAGTGGTAATTTTGGCGATCATAAATCAGTTGGTGATGGTTTGTATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGATTTATTATGCACAATACAAAGATGTAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACGCAGAAAGCAGATATCGCTAAAGCAAAAGCATTATGGGAAGAGATTAAGCAGAAAGAGGAGATAAATGTATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174728 NZ_CP062380:c2380027-2379967 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin