Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2348004..2348527 Replicon chromosome
Accession NZ_CP062380
Organism Staphylococcus aureus strain NAS_AN_076

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag IF704_RS11530 Protein ID WP_000074048.1
Coordinates 2348261..2348527 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag IF704_RS11525 Protein ID WP_000587617.1
Coordinates 2348004..2348261 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF704_RS11505 (2343083) 2343083..2344276 + 1194 WP_000675402.1 MFS transporter -
IF704_RS11510 (2344500) 2344500..2345249 - 750 WP_000072454.1 CPBP family lipoprotein N-acylation protein LnsB -
IF704_RS11515 (2345444) 2345444..2347021 + 1578 WP_000971447.1 FMN-binding glutamate synthase family protein -
IF704_RS11520 (2347189) 2347189..2347644 - 456 WP_000732082.1 DUF1307 domain-containing protein -
IF704_RS11525 (2348004) 2348004..2348261 + 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF704_RS11530 (2348261) 2348261..2348527 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
IF704_RS11535 (2348883) 2348883..2349959 + 1077 WP_001076675.1 M42 family metallopeptidase -
IF704_RS11540 (2350304) 2350304..2350966 + 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
IF704_RS11545 (2350959) 2350959..2351735 + 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
IF704_RS11550 (2352130) 2352130..2353317 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T174727 WP_000074048.1 NZ_CP062380:2348261-2348527 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174727 NZ_CP081479:2459-2836 [Pseudomonas aeruginosa]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT174727 WP_000587617.1 NZ_CP062380:2348004-2348261 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174727 NZ_CP081479:2817-3152 [Pseudomonas aeruginosa]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References