Detailed information of TA system TA174722

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 62794..63132
• Replicon: chromosome
• Accession: NZ_CP062380
• Organism: Staphylococcus aureus strain NAS_AN_076

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: IF704_RS00455
• Protein ID: WP_072357969.1
• Coordinates: 62794..62970 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	62958..63132 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF704_RS00435	57960..61745	+	3786	WP_240022153.1	phage tail spike protein	-
IF704_RS00440	61735..61887	+	153	WP_000654329.1	hypothetical protein	-
IF704_RS00445	61934..62221	+	288	WP_001040255.1	hypothetical protein	-
IF704_RS00450	62277..62651	+	375	WP_000340977.1	hypothetical protein	-
IF704_RS00455	62794..62970	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	62958..63132	-	175	-	-	Antitoxin
IF704_RS00465	63182..63436	+	255	WP_000611512.1	phage holin	-
IF704_RS00470	63448..64203	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF704_RS00475	64394..64885	+	492	WP_000920038.1	staphylokinase	-
IF704_RS00480	65536..65871	+	336	Protein_95	SH3 domain-containing protein	-
IF704_RS00485	66382..66732	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
IF704_RS00490	66784..67044	-	261	WP_001791826.1	hypothetical protein	-
IF704_RS00495	67355..67534	-	180	WP_000669791.1	hypothetical protein	-
IF704_RS00500	67906..68103	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn / sak / scn	52..66732	66680

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T174722 WP_072357969.1 NZ_CP062380:62794-62970 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174722 NZ_CP081477:c4985269-4984979 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCGACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGCGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT174722 NZ_CP062380:c63132-62958 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin