Detailed information of TA system TA174716

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2127452..2127636
• Replicon: chromosome
• Accession: NZ_CP062378
• Organism: Staphylococcus aureus strain NAS_AN_079

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: IF705_RS10805
• Protein ID: WP_000482652.1
• Coordinates: 2127529..2127636 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2127452..2127512 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF705_RS10790	2122907..2123038	-	132	WP_223197975.1	hypothetical protein	-
IF705_RS10795	2123305..2125038	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
IF705_RS10800	2125063..2126826	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2127452..2127512	+	61	-	-	Antitoxin
IF705_RS10805	2127529..2127636	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
IF705_RS10810	2127770..2128156	-	387	WP_000779360.1	flippase GtxA	-
IF705_RS10815	2128424..2129566	+	1143	WP_001176863.1	glycerate kinase	-
IF705_RS10820	2129626..2130285	+	660	WP_000831298.1	membrane protein	-
IF705_RS10825	2130467..2131678	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF705_RS10830	2131801..2132274	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174716 WP_000482652.1 NZ_CP062378:c2127636-2127529 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174716 NZ_CP081477:60863-61441 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT174716 NZ_CP062378:2127452-2127512 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin