Detailed information of TA system TA174704

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 19747..20085
• Replicon: chromosome
• Accession: NZ_CP062378
• Organism: Staphylococcus aureus strain NAS_AN_079

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IF705_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 19747..19923 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19911..20085 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF705_RS00085	14982..18767	+	3786	WP_020808017.1	phage tail spike protein	-
IF705_RS00090	18757..18909	+	153	WP_001153681.1	hypothetical protein	-
IF705_RS00095	18956..19243	+	288	WP_001040254.1	hypothetical protein	-
IF705_RS00100	19301..19597	+	297	WP_042853951.1	DUF2951 domain-containing protein	-
IF705_RS00105	19747..19923	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	19911..20085	-	175	-	-	Antitoxin
IF705_RS00115	20135..20389	+	255	WP_000611512.1	phage holin	-
IF705_RS00120	20401..21156	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF705_RS14020	21690..21812	+	123	WP_000346420.1	hypothetical protein	-
IF705_RS00125	22054..22881	-	828	WP_000136054.1	alpha/beta hydrolase	-
IF705_RS00130	22954..24153	-	1200	WP_000286459.1	NADH-dependent flavin oxidoreductase	-
IF705_RS00135	24249..24341	+	93	WP_001802007.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1..21156	21155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T174704 WP_011447039.1 NZ_CP062378:19747-19923 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174704 NZ_CP081457:c1082400-1082125 [Pseudomonas syringae pv. actinidifoliorum ICMP 18803]
ATGGAGCTGATGTGGACAAGCAAAGCGCTATCTGACGTCGCCCGCCTGTATGATTTTTTAGCGGTAGCAAACCAACCCGC
TGCCGCCCAGACCGTACAGAAGCTTACAGCGGCGCCGATCATGCTCCTTTCCAACCCGCGGATTGGTGAGCGTCTGGAGG
AGTTTGAGCCCCGGGATGTGCGCAGAATTCAGATAGGCCGCTATGAAATGCGCTACGAAATTGTGGACTCAACAATTTAT
CTGTTGCGGCTGTGGCATACACGCGAGGATCGGTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT174704 NZ_CP062378:c20085-19911 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGACTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin