Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2731306..2731720 | Replicon | chromosome |
| Accession | NZ_CP062376 | ||
| Organism | Staphylococcus aureus strain NAS_AN_099 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | IF707_RS13420 | Protein ID | WP_025174939.1 |
| Coordinates | 2731306..2731557 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | IF707_RS13425 | Protein ID | WP_000028424.1 |
| Coordinates | 2731547..2731720 (+) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF707_RS13380 (2727012) | 2727012..2727932 | + | 921 | WP_000138475.1 | recombinase RecT | - |
| IF707_RS13385 (2727941) | 2727941..2728630 | + | 690 | WP_240017451.1 | MBL fold metallo-hydrolase | - |
| IF707_RS13390 (2728631) | 2728631..2729101 | + | 471 | WP_000934760.1 | single-stranded DNA-binding protein | - |
| IF707_RS13395 (2729131) | 2729131..2730024 | + | 894 | WP_000148335.1 | DnaD domain-containing protein | - |
| IF707_RS13400 (2730031) | 2730031..2730249 | + | 219 | WP_000338527.1 | hypothetical protein | - |
| IF707_RS13405 (2730258) | 2730258..2730662 | + | 405 | WP_000401978.1 | RusA family crossover junction endodeoxyribonuclease | - |
| IF707_RS13410 (2730675) | 2730675..2731045 | + | 371 | Protein_2600 | SA1788 family PVL leukocidin-associated protein | - |
| IF707_RS13415 (2731049) | 2731049..2731291 | + | 243 | WP_000131381.1 | phi PVL orf 51-like protein | - |
| IF707_RS13420 (2731306) | 2731306..2731557 | + | 252 | WP_025174939.1 | DUF1024 family protein | Toxin |
| IF707_RS13425 (2731547) | 2731547..2731720 | + | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| IF707_RS13430 (2731721) | 2731721..2732002 | + | 282 | WP_000454994.1 | hypothetical protein | - |
| IF707_RS13435 (2732003) | 2732003..2732164 | + | 162 | WP_000889683.1 | hypothetical protein | - |
| IF707_RS13440 (2732179) | 2732179..2732712 | + | 534 | WP_240017425.1 | dUTP diphosphatase | - |
| IF707_RS13445 (2732749) | 2732749..2732955 | + | 207 | WP_000195826.1 | DUF1381 domain-containing protein | - |
| IF707_RS13450 (2732952) | 2732952..2733143 | + | 192 | Protein_2608 | hypothetical protein | - |
| IF707_RS13455 (2733144) | 2733144..2733347 | + | 204 | WP_001072793.1 | hypothetical protein | - |
| IF707_RS13460 (2733340) | 2733340..2733465 | + | 126 | WP_031783376.1 | transcriptional regulator | - |
| IF707_RS13465 (2733465) | 2733465..2733665 | + | 201 | WP_001570807.1 | DUF1514 family protein | - |
| IF707_RS13470 (2733688) | 2733688..2734149 | + | 462 | WP_000282756.1 | hypothetical protein | - |
| IF707_RS13475 (2734264) | 2734264..2734716 | + | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| IF707_RS13480 (2734732) | 2734732..2735076 | + | 345 | WP_000817289.1 | HNH endonuclease | - |
| IF707_RS13485 (2735205) | 2735205..2735672 | + | 468 | WP_000919026.1 | phage terminase small subunit P27 family | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | groEL / hlb | 2703424..2735672 | 32248 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9361.22 Da Isoelectric Point: 3.8464
>T174703 WP_025174939.1 NZ_CP062376:2731306-2731557 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T174703 NZ_CP081354:c2590719-2590453 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT174703 WP_000028424.1 NZ_CP062376:2731547-2731720 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT174703 NZ_CP081354:c2590976-2590719 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|