Detailed information of TA system TA174698

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2582532..2582810
• Replicon: chromosome
• Accession: NZ_CP062376
• Organism: Staphylococcus aureus strain NAS_AN_099

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF707_RS12610
• Protein ID: WP_001802298.1
• Coordinates: 2582532..2582636 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2582632..2582810 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF707_RS12595	2579329..2580111	+	783	WP_045177727.1	ABC transporter ATP-binding protein	-
IF707_RS12600	2580178..2581035	+	858	WP_045177730.1	HAD family hydrolase	-
IF707_RS12605	2581694..2581852	-	159	WP_001792784.1	hypothetical protein	-
IF707_RS12610	2582532..2582636	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2582632..2582810	-	179	-	-	Antitoxin
IF707_RS12620	2583135..2584226	-	1092	WP_045177732.1	lytic regulatory protein	-
IF707_RS12625	2584492..2585472	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
IF707_RS12630	2585474..2585794	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF707_RS12635	2585946..2586611	+	666	WP_045177733.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174698 WP_001802298.1 NZ_CP062376:2582532-2582636 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174698 NZ_CP081354:c2192147-2191785 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Nucleotide

• Length: 179 bp

>AT174698 NZ_CP062376:c2582810-2582632 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin