Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2328062..2328579 Replicon chromosome
Accession NZ_CP062376
Organism Staphylococcus aureus strain NAS_AN_099

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF707_RS11270 Protein ID WP_000113262.1
Coordinates 2328313..2328579 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF707_RS11265 Protein ID WP_000584499.1
Coordinates 2328062..2328313 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF707_RS11235 (2323760) 2323760..2324479 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF707_RS11240 (2324476) 2324476..2325207 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF707_RS11245 (2325304) 2325304..2326554 - 1251 WP_001012241.1 FemA/FemB family glycyltransferase FmhA -
IF707_RS11250 (2326809) 2326809..2327171 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF707_RS11255 (2327190) 2327190..2327789 + 600 WP_000162812.1 DsbA family protein -
IF707_RS11260 (2327796) 2327796..2327897 + 102 WP_001791744.1 hypothetical protein -
IF707_RS11265 (2328062) 2328062..2328313 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF707_RS11270 (2328313) 2328313..2328579 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF707_RS11275 (2328614) 2328614..2328685 + 72 WP_223200558.1 hypothetical protein -
IF707_RS11280 (2328873) 2328873..2330423 + 1551 WP_045177665.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF707_RS11285 (2330609) 2330609..2331076 + 468 WP_000153346.1 SRPBCC domain-containing protein -
IF707_RS11290 (2331160) 2331160..2331342 + 183 WP_000230294.1 hypothetical protein -
IF707_RS11295 (2331559) 2331559..2332383 + 825 WP_045177662.1 formate/nitrite transporter family protein -
IF707_RS11300 (2332616) 2332616..2333152 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174696 WP_000113262.1 NZ_CP062376:2328313-2328579 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174696 NZ_CP081354:c1991299-1991147 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT174696 WP_000584499.1 NZ_CP062376:2328062-2328313 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174696 NZ_CP081354:c1991923-1991324 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References