Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2355924..2356441 | Replicon | chromosome |
| Accession | NZ_CP062372 | ||
| Organism | Staphylococcus aureus strain NAS_AN_109 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | IF710_RS11615 | Protein ID | WP_000113262.1 |
| Coordinates | 2355924..2356190 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | IF710_RS11620 | Protein ID | WP_000584499.1 |
| Coordinates | 2356190..2356441 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF710_RS11585 (IF710_11530) | 2351347..2351883 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| IF710_RS11590 (IF710_11535) | 2352117..2352941 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| IF710_RS11595 (IF710_11540) | 2353158..2353340 | - | 183 | WP_000079142.1 | hypothetical protein | - |
| IF710_RS11600 (IF710_11545) | 2353427..2353894 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| IF710_RS11605 (IF710_11550) | 2354080..2355630 | - | 1551 | WP_000727763.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IF710_RS11610 | 2355818..2355889 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| IF710_RS11615 (IF710_11555) | 2355924..2356190 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| IF710_RS11620 (IF710_11560) | 2356190..2356441 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IF710_RS11625 (IF710_11565) | 2356606..2356686 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| IF710_RS11630 (IF710_11570) | 2356714..2357313 | - | 600 | WP_000162803.1 | DsbA family protein | - |
| IF710_RS11635 (IF710_11575) | 2357332..2357694 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| IF710_RS11640 (IF710_11580) | 2357949..2359199 | + | 1251 | WP_001012228.1 | FemA/FemB family glycyltransferase FmhA | - |
| IF710_RS11645 (IF710_11585) | 2359296..2360027 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| IF710_RS11650 (IF710_11590) | 2360024..2360743 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T174683 WP_000113262.1 NZ_CP062372:c2356190-2355924 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T174683 NZ_CP081346:c5677819-5677541 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT174683 WP_000584499.1 NZ_CP062372:c2356441-2356190 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT174683 NZ_CP081346:c5677529-5677224 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|