Detailed information of TA system TA174678

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1814492..1814672
• Replicon: chromosome
• Accession: NZ_CP062372
• Organism: Staphylococcus aureus strain NAS_AN_109

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF710_RS08650
• Protein ID: WP_001801861.1
• Coordinates: 1814492..1814587 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1814615..1814672 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF710_RS08615 (IF710_08580)	1809533..1810159	+	627	WP_000669021.1	hypothetical protein	-
IF710_RS08620 (IF710_08585)	1810200..1810541	+	342	WP_000627547.1	DUF3969 family protein	-
IF710_RS08625 (IF710_08590)	1810642..1811214	+	573	WP_000414206.1	hypothetical protein	-
IF710_RS08630 (IF710_08595)	1811412..1812040	-	629	Protein_1700	ImmA/IrrE family metallo-endopeptidase	-
IF710_RS08635 (IF710_08600)	1812340..1812516	-	177	WP_000375476.1	hypothetical protein	-
IF710_RS08640 (IF710_08605)	1812527..1812910	-	384	WP_000070811.1	hypothetical protein	-
IF710_RS08645 (IF710_08610)	1813595..1814041	-	447	WP_000747802.1	DUF1433 domain-containing protein	-
IF710_RS08650 (IF710_08615)	1814492..1814587	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1814615..1814672	-	58	-	-	Antitoxin
IF710_RS08655 (IF710_08620)	1814710..1814811	+	102	WP_001791232.1	hypothetical protein	-
IF710_RS08660 (IF710_08625)	1814789..1814971	-	183	Protein_1706	transposase	-
IF710_RS08665 (IF710_08630)	1815159..1815533	-	375	WP_000695818.1	DUF1433 domain-containing protein	-
IF710_RS08670 (IF710_08635)	1815555..1815833	-	279	WP_001798632.1	DUF1433 domain-containing protein	-
IF710_RS08675 (IF710_08640)	1816112..1816555	-	444	WP_000742594.1	DUF1433 domain-containing protein	-
IF710_RS08680 (IF710_08645)	1817203..1818321	-	1119	WP_000072558.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1788676..1843567	54891

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174678 WP_001801861.1 NZ_CP062372:1814492-1814587 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174678 NZ_CP081346:1919917-1920504 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT174678 NZ_CP062372:c1814672-1814615 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin