Detailed information of TA system TA174670

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2582569..2582831
• Replicon: chromosome
• Accession: NZ_CP062370
• Organism: Staphylococcus aureus strain NAS_AN_111

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF711_RS12700
• Protein ID: WP_001802298.1
• Coordinates: 2582569..2582673 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2582668..2582831 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF711_RS12685	2579366..2580148	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
IF711_RS12690	2580216..2581073	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
IF711_RS12695	2581731..2581889	-	159	WP_001792784.1	hypothetical protein	-
IF711_RS12700	2582569..2582673	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2582668..2582831	-	164	-	-	Antitoxin
IF711_RS12710	2583106..2584197	-	1092	WP_240021959.1	transcriptional regulator	-
IF711_RS12715	2584463..2585440	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
IF711_RS12720	2585442..2585762	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF711_RS12725	2585914..2586579	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174670 WP_001802298.1 NZ_CP062370:2582569-2582673 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174670 NZ_CP081344:120093-120560 [Pantoea ananatis]
TTGAAGCTCTATCGCATGACCAAAACGCGCTATCTGGGGTCGGCCTGGAGCGGTTTTGGTGCCCGCGAAGGCGGCGGGCG
CTGGAACAGCGTCGGCGTATCAATGGTTTACGCTTCTGAAACCGCTTCCCTCACCATGCTGGAGACGCTTATCCATCTGC
AAAGCGCCAGCGTGCTGGACTTTTTTACCCTCATGAGCATTGACGTTCCCGACAGGCTGATTGAATGGATTGATATCAAG
CAACTTCCTGACGACTGGGCCGCACCGGAAGCGCCTGCAGCGCTGCGTTTATTTGGTGATGCCTGGATACAAAGCGGGGG
ATCGGTCGCACTGCGCGTGCCCAGCGCCCTTTCGCCCGTAGAATCGAATTATCTTCTCAATCCGGAACATCCCGAATTCA
ATGCTATCGTCAGGCAGGCGGTAAACATCCCCTTCCTTTTTGACGTACGCTTCTCCCGACAGGCATAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT174670 NZ_CP062370:c2582831-2582668 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin